Mild acid response nanocarriers have been intensively attracted interest in the field of drug delivery on the account of the responsive\nproperty to abnormal physiological environment as well as the original property to normal physiological environment. However,\nthe drug delivery system lacks capacity of precise localization to abnormal tissue or targeted cells. Therefore, a magnetic and pHsensitive\ncomposite nanoparticle was designed and prepared by double water-in-oil-in-water (W/O/W) emulsion using acetylated\nÃ?²-cyclodextrin (Ac-Ã?²-CD) as a dominant material to realize the pH response and Fe3O4 as a component to realize magnetic\nresponse. The surface chemical characteristic was characterized by Fourier-transformed infrared spectroscopy (FTIR) using pure\nAc-Ã?²-CD nanoparticle as a control and exhibits the typical chemical characteristic of Ac-Ã?²-CD. Furthermore, the structural\ninformation was tracked by X-ray diffraction (XRD) and thermogravimetric analysis (TG). It was found that composite\nnanoparticle possessed structural characteristic of both Ac-Ã?²-CD and Fe3O4. Composite nanoparticle exhibited sphere and\ntwo-phase morphology with the diameter of about 200ââ?¬â??250nm depending on their detection method and zeta potential of âË?â??12\nto âË?â??14 mV. More importantly, irreversible pH response property and reversible magnetic responsive properties either in\nneutral environment or in mild acid environment for the composite nanoparticle were confirmed in the research. Finally, drug\nloading and release behavior were investigated through preliminary in vitro evaluation.
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